Consider the following commercially available bone substitute materials: InterOss®, nanOss® and MinerOss®. 1. Characterize them in terms of source, forms available and clinical applications. 2. Compare their performance indicating advantages and limitations of each. Present evidence from in vitro and/or in vivo and/or clinical studies available. 3. Compare their potential to activate the immune system and the development of infections following implantation. Submit no more than 2 pages A4 (references, images and tables not included), with normal margins (all margins = 2.54 cm) written in arial font size 10, single-space paragraph. The more sources the better ATTENTION: No more than 30% plagiarism will be allowed.